Mechanism that maintains stem cells readiness identified

ScienceDaily (May 31, 2012) ? An immune-system receptor plays an unexpected but crucially important role in keeping stem cells from differentiating and in helping blood cancer cells grow, researchers at UT Southwestern Medical Center report today in the journal Nature.

"Cancer cells grow rapidly in part because they fail to differentiate into mature cells. Drugs that induce differentiation can be used to treat cancers," said Dr. Chengcheng "Alec" Zhang, assistant professor in UT Southwestern's departments of physiology and developmental biology. "Our research identified a protein receptor on cancer cells that inhibits differentiation, and knowing the identity of this protein should facilitate the development of new drugs to treat cancers."

The family of proteins investigated in the study could help open a new field of biology integrating immunology with stem cell and cancer research, he added.

"The receptor we identified turned out to be a protein called a classical immune inhibitory receptor, which is known to maintain stemness of normal adult stem cells and to be important in the development of leukemia," he said.

Stemness refers to the blood stem cells' potential to develop into a range of different kinds of cells as needed, for instance to replenish red blood cells lost to bleeding or to produce more white blood cells to fight off infection. Once stem cells differentiate into adult cells, they cannot go back to being stem cells. Current thinking is that the body has a finite number of stem cells and it is best to avoid depleting them, Dr. Zhang explained.

Prior to this study, no high-affinity receptors had been identified for the family of seven proteins called the human angiopoetic-like proteins. These seven proteins are known to be involved in inflammation, supporting the activity of stem cells, breaking down fats in the blood, and growing new blood vessels to nourish tumors. Because the receptor to which these proteins bind had not been identified, the angiopoetic-like proteins were referred to as "orphans," he said.

The researchers found that the human immune-inhibitory receptor LILRB2 and a corresponding receptor on the surface of mouse cells bind to several of the angiopoetic-like proteins. Further studies, Dr. Zhang said, showed that two of the seven family members bind particularly well to the LILRB2 receptor and that binding exerts an inhibitory effect on the cell, similar to a car's brakes.

In the case of stem cells, inhibition keeps them in their stem state. They retain their potential to mature into all kinds of blood cells as needed but they don't use up their energy differentiating into mature cells. That inhibition helps stem cells maintain their potential to create new stem cells because in addition to differentiation, self-renewal is the cells' other major activity, Dr. Zhang said. He stressed that the inhibition doesn't cause them to create new stem cells but does preserve their potential to do so.

In future research, the scientists hope to find subtle differences between stem cells and leukemia cells that will identify treatments to block the receptors' action only in leukemia.

Other UT Southwestern researchers involved in the study from the departments of physiology and developmental biology include postdoctoral researchers Dr. ChangHao Cui, Dr. Xiaoli Chen, Dr. Chaozheng Zhang, Dr. HoangDinh Huynh, and Dr. Xunlei Kang; senior research associates Robert Silvany and Jiyuan Li; and graduate student Xuan Wan. Researchers from the department of immunology include former technician Alberto Puig Cant? and Dr. E. Sally Ward, professor of immunology.

Former UT Southwestern researchers include lead author and former instructor of physiology Dr. Junke Zheng, now at Shanghai Jiao Tong University School of Medicine in Shanghai, China; Dr. Masato Umikawa, now at the University of Ryukyus in Okinawa, Japan; Dr. Shu-Hsia Chen, now at Mount Sinai School of Medicine in New York City; Dr. Huan-You Wang, now at the University of California, San Diego; and Dr. Jingxiao Ye, now at the University of Texas at Dallas.

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The above story is reprinted from materials provided by UT Southwestern Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Junke Zheng, Masato Umikawa, Changhao Cui, Jiyuan Li, Xiaoli Chen, Chaozheng Zhang, HoangDinh Hyunh, Xunlei Kang, Robert Silvany, Xuan Wan, Jingxiao Ye, Alberto Puig Cant?, Shu-Hsia Chen, Huan-You Wang, E. Sally Ward, Cheng Cheng Zhang. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature, 2012; 485 (7400): 656 DOI: 10.1038/nature11095

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Exclusive look at the 'Care Bears' TV return

By Anna Chan

Remember Tenderheart Bear? Grumpy Bear? Funshine Bear? Well, those cuddly and lovable characters, their belly talent badges, as well as their magical?kingdom in the clouds are all back in The Hub's new series "Care Bears: Welcome to Care-a-Lot." This latest version comes 27 years after the original TV show launched, and 31 years after American Greetings introduced the characters on greeting cards.

Check out this exclusive sneak peek The Hub shared with TODAY.com, which features the three bears welcoming little girl Penny to Care-a-Lot:

The show will also bring back other classic bears as well as introduce a few new ones. "Care Bears" premieres June 2?at 5 a.m. PT/8 a.m. ET on The Hub. Check The Hub's website to see which channel the network is on in your area.

Which bear was your favorite? Tell us on our?Facebook page!

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NY top court weighs claim from investment loss

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Needle-free device could deliver powdered drugs

"You'll just feel a sharp sting..." No, don't look away, because these words may soon be a thing of the past. A needleless device that jets medicine through the skin could bring an end to painful injections. It could also provide developing countries with a way to deliver powdered drugs, which do not require refrigeration.

There are several needleless systems already on the market, which use explosive forces to eject a liquid drug through a narrow opening at pressures high enough to penetrate the skin. However, they are designed to eject the drug in an "all or nothing" fashion, releasing the same amount of medicine to the same depth every time.

To counter this limitation, Ian Hunter and Nora Hogan at the Massachusetts Institute of Technology, together with Andrew Taberner at the University of Auckland, New Zealand, developed a device based on a "Lorentz force" mechanism.

This consists of a coiled wire that is wrapped around a powerful magnet at one end and attached to a piston at the other. When a current is applied to the wire it interacts with the magnet, pushing the piston forwards. This in turn pushes a liquid drug through a hole the width of a mosquito's proboscis and into the skin. The force can be controlled by varying the current applied to the coil, which allows precise control over dose and depth.

Targeted drugs

Because existing needleless devices offer less control they generally deliver less of the drug to the target site. In some cases, say Hunter's team, just 10 per cent of the drug reaches the correct tissue. Their tests in animal tissue showed that the new device delivers more than 80 per cent of the drug to the target.

The team is now working on adding a vibratory mechanism to their device to allow it to transform powdered drugs into a form suitable for injection. "If you vibrate a powder the drug crystals jiggle around, become energised and behave in a similar way to a fluid," says Hunter.

If successful, their device could help increase the availability of drugs in the developing world, because powdered drugs are more stable than liquid drugs at room temperature ? liquid drugs must be refrigerated to keep them stable. "It's early days but we're pretty excited," says Hunter.

Journal reference: Medical Engineering & Physics, DOI: 10.1016/j.medengphy.2011.12.010

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Romney welcomes mass expulsion of Syrian diplomats

In this photo taken May 29, 2012 Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks in Craig, Colo. Romney is calling for more ?assertive measures? against Syrian President Bashar Assad, including arming the Syrian opposition. The Obama administration so far has declined to help arm the opposition. (AP Photo/Mary Altaffer)

In this photo taken May 29, 2012 Republican presidential candidate, former Massachusetts Gov. Mitt Romney speaks in Craig, Colo. Romney is calling for more ?assertive measures? against Syrian President Bashar Assad, including arming the Syrian opposition. The Obama administration so far has declined to help arm the opposition. (AP Photo/Mary Altaffer)

WASHINGTON (AP) ? Republican presidential candidate Mitt Romney is calling for more "assertive measures" against Syrian President Bashar Assad, including arming the Syrian opposition. The Obama administration so far has declined to help arm the opposition.

Romney said in a written statement that he welcomed Tuesday's mass expulsion of Syrian diplomats by the U.S. and other countries to protest the weekend massacre of dozens of civilians, including children.

But he said the move underscores the need for stronger measures to end Assad's regime. He said President Barack Obama's "lack of leadership" had created a "policy of paralysis" that has led to the killing of an estimated 10,000 Syrians.

Romney called for increasing pressure on Russia to stop selling arms to Syria, and for Russia to end its obstruction at the United Nations.

Associated Press

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The Stunning All New Samsung Galaxy S III Smartphone.

Samsung Electronics has been a pioneer in the field of consumer electronics and information technology. The company?s product portfolio comprises of home appliances, mobile phones, televisions, computers & related accessories, and tablet PCs, among others. The company?s lines of businesses include digital media, semiconductors, telecommunication networks, and digital appliances. The company?s venture into the upcoming market sectors such as the smart phone and tablet market has proven to be fruitful. Samsung has competed with dominant players like Apple and Nokia in the smart phone market, and is trending towards overhauling their market dominance in the near future. Samsung has competed in this highly-competed market sector by unveiling innovative and technologically advanced smart phone models at attractive price points.

In fact, Samsung has overtaken some of the major Japanese smart phone manufacturers in terms of units sold, and also looks to be on path to dethrone the authority of Apple in the smart phone market.

Samsung has gained world over brand recognition and it certainly looks like it is going to dominate the smart phone market for many more years to come. A testament to this saying is its unveiling of technologically advanced smart phones such as the Galaxy S III model. The phone was officially launched on May 2012, and has amassed rave reviews since then.

The advert of the new Samsung Galaxy S III was considered to be a direct rival to Apple?s iPhone 4S and Nokia Lumia series. When analyzing the market reports on the unit sales and customer reviews, it is evident that the Samsung Galaxy S III has certainly scored slightly more than the other two smart phone models. The very first look at the S III is certain to lure the person to splurge the cash on it to buy it.

The Samsung Galaxy S III comes with a super AMOLED capacitive touch-screen and operates on the Android Ice Cream Sandwich operating system. Its other features include:
?8 megapixel primary camera with LED flash and 2 megapixel secondary camera.
?Sensors for accelerometer, gyro, RGB sensor, proximity, compass, and barometer.
?2G, 3G, and 4G LTE network compatible.
?Memory extendible up to 64 gigabytes.
?1 GB RAM and minimum internal memory of 16 GB.
?HTML and Adobe Flash browsers.

As the phone works on the Android platform, there are loads of apps which can be downloaded from the Google Android app store. Samsung sells this wonderful smart phone through company-operated retail stores as well as other third-party retailers. There are also loads of deals and offers to choose from, when opting to purchase the phone through any of the renowned online retailers such as Amazon and Ebay.
The Samsung Galaxy S III is a splendid next generation smart phone, which will certainly amaze you with its technologies and features. With this smart phone model, Samsung has cemented its place as the market leader in the smart phone marketplace.

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LINPAC duo to speak at EuPC and CMT PET Conference

Alan Davey, our Director of Innovation, is speaking at this year?s European Plastics Converters Association conference in Vienna which runs from May 1 to June 1.
The EuPC is the EU-level Trade Association, based in Brussels, representing European Plastics Converters. Plastics converters (sometimes called "Processors") are the heart of the plastics industry.
Alan?s chosen topic is Innovation Challenges and Opportunities in Rigid Packaging Today.
Alan will begin his talk with a quotation from Winston Churchill - "A pessimist sees the difficulty in every opportunity; an optimist sees the opportunity in every difficulty" - which neatly sums up the tone and content of his address.
In his talk Alan will address the challenges facing the industry covering the
changing needs of the market; the effectiveness of packaging; the need to drive down food waste and delivering environmental benefits. He will also look as some of the some of the innovations driven by this view.
At the same time as Alan is giving his address Jo Stephenson, our Vice President Marketing & Innovation, will be talking at the CMT PET Conference, in Strasbourg.
The CMT PET Conference offers up to date business information on regional PET resin and packaging markets in Europe with a program agenda that incorporates latest market and technological developments in the entire PET Value Chain.

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U.N. Security Council condemns Syria over massacre

AMMAN/UNITED NATIONS (Reuters) - The U.N. Security Council on Sunday unanimously condemned the killing of at least 108 people, including many children, in the Syrian town of Houla, a sign of mounting outrage at the massacre that the government and rebels blamed on each other.

Images of bloodied and lifeless young bodies, laid carefully side by side after the onslaught on Friday, triggered shock around the world and underlined the failure of a six-week-old U.N. ceasefire plan to stop the violence.

Western and Arab states opposed to Syrian President Bashar al-Assad put the blame for the deaths squarely on the government. But Damascus rejected the charge.

"The Security Council condemned in the strongest possible terms the killings, confirmed by United Nations observers, of dozens of men, women and children and the wounding of hundreds more in the village of (Houla), near Homs, in attacks that involved a series of government artillery and tank shellings on a residential neighborhood," the non-binding statement said.

"Such outrageous use of force against civilian population constitutes a violation of applicable international law and of the commitments of the Syrian Government under United Nations Security Council Resolutions," the statement said.

The United Nations believes that at least 108 people were killed in Houla, U.N. peacekeeping chief Herve Ladsous said.

Russia, which along with China has vetoed two Security Council resolutions calling for tougher action against Damascus, said the "tragic" events in Syria deserve condemnation and called for a U.N. assessment of the violence there.

Russian Deputy U.N. Ambassador Alexander Pankin said the circumstances surrounding the massacre were "murky" and rejected the idea that the evidence clearly showed Damascus was guilty.

The head of the U.N. observer force, General Robert Mood, briefed the council by video link. Pankin said Mood "did not link directly the (army's) shelling with numbers of deaths."

U.N. Secretary-General Ban Ki-moon sent the council a letter that appeared to give ammunition to both sides.

He said the observers "viewed the bodies of the dead and confirmed from an examination of ordnance that artillery and tank shells were fired at a residential neighborhood." The rebels do not have artillery and tanks.

But Ban also said U.N. monitors observed shotgun wounds on some of the bodies, which could indicate close-range attacks by rebels, as Pankin suggested, or could be the result of follow-up attacks by the army after it stopped shelling.

"While the detailed circumstances are unknown, we can confirm that there has been artillery and mortar shelling," Ban said. "There have also been other forms of violence, including shootings at close range and severe physical abuse."

International mediator Kofi Annan and Ladsous are expected to brief the council on Syria on Wednesday.

RUSSIA OPPOSES SANCTIONS

British Ambassador Mark Lyall Grant did not have any doubts about who was responsible for the events in Houla.

"It seems quite clear that the massacre in Houla was caused by heavy bombardment, by government artillery and tanks," Lyall Grant said. After the council meeting he said it was time for the council to discuss "next steps" - a code word for sanctions.

"The fact is, it is an atrocity and it was perpetrated by the Syrian government," Lyall Grant said.

Russia, however, rejects the idea of sanctioning its ally and has accused the United States and Europe of pursuing Libya-style regime change in Syria, where Assad has been trying to crush a 14-month-old insurgency that began peacefully but has become increasingly militarized.

Syria is home to the Russian navy's only warm-water port outside of the former Soviet Union and is a major purchaser of Russian weapons.

Syrian Ambassador Bashar Ja'afari reiterated his government's denial, saying the massacre was committed by "armed terrorist groups" - the Syrian government's term for the rebels. He also dismissed the "tsunami of lies" of the British, French and German envoys, who blamed the government for the massacre.

"Women, children and old men were shot dead. This is not the hallmark of the heroic Syrian army," Foreign Ministry spokesman Jihad Makdesi told reporters in Damascus.

The Houla massacre is among the worst carnage in the uprising against Assad, which has cost about 10,000 lives.

In his public comments, Mood has called the killings "a very tragical expression" of the situation in Syria, but refrained from apportioning blame.

"For myself, I have had patrols on the ground all the day yesterday afternoon and today we are gathering facts on the ground and then we will draw our own conclusions," Mood told the BBC in a telephone interview on Sunday.

But Ban and Annan, the U.N. and Arab League envoy for Syria, accused the Syrian government of using artillery in populated areas.

"This appalling and brutal crime involving indiscriminate and disproportionate use of force is a flagrant violation of international law and of the commitments of the Syrian Government to cease the use of heavy weapons in population centers and violence in all its forms," they said in a joint statement on Saturday.

Annan is planning to visit Damascus soon. Ja'afari suggested Annan could arrive as early as Monday.

Russia's Pankin said that whoever caused the massacre wanted to disrupt Annan's visit. "We don't believe the Syrian government would be interested in spoiling the visit of (Annan) ... by doing something like that."

"CORPSES WERE PILED ON TOP OF EACH OTHER"

Opposition activists said Assad's forces shelled Houla after a protest and then clashed with fighters from the Sunni Muslim-led insurgency.

Activists say Assad's "shabbiha" militia, loyal to an establishment dominated by members of the minority Alawite sect, then hacked dozens of the victims to death, or shot them.

Maysara al-Hilawi said he saw the bodies of six children and their parents in a ransacked house in the town.

"The Abdelrazzak family house was the first one I entered. The children's corpses were piled on top of each other, either with their throats cut or shot at close range," Hilawi, an opposition activist, said by telephone from the area.

A video distributed by activists showed an injured woman, who said she had survived the massacre, blaming shabbiha militiamen for the carnage.

"They entered our homes ... men wearing fatigues herding us like sheep in the room and started spraying bullets at us," the woman said. "My father died and my brother, my mother's only son. Seven sisters were killed," the woman said lying next to another injured woman and near a baby with a chest wound.

The White House said it was horrified by credible reports of brutal attacks on women and children in Houla.

"These acts serve as a vile testament to an illegitimate regime that responds to peaceful political protest with unspeakable and inhuman brutality," a White House spokesman said.

The Gulf Cooperation Council of Sunni-led monarchies accused Assad's soldiers of using excessive force and urged the international community to "assume its responsibilities to halt the daily bloodshed in Syria."

EU foreign policy chief Catherine Ashton spoke of a "heinous act perpetrated by the Syrian regime against its own civilian population" in a statement on Sunday. U.N. human rights chief Navi Pillay said in a statement that it could amount to crimes against humanity or other war crimes.

On Sunday, at least 30 people were killed when Syrian army tanks shelled residential neighborhoods in the city of Hama that have been serving as bases for rebel attacks against loyalist forces, opposition activists said. The reports could not be verified independently.

Although the ceasefire plan negotiated by Annan has failed to stop the violence, the United Nations is nearing full deployment of a 300-strong unarmed observer force meant to monitor a truce.

The plan calls for a truce, withdrawal of troops from cities and dialogue between government and opposition.

Syria calls the revolt a "terrorist" conspiracy run from abroad, a veiled reference to Sunni Muslim Gulf powers that want to see weapons provided to the insurgents.

(Additional reporting by Jeff Mason in Washington, Suleiman Al-Khalidi in Amman, Avril Ormsby in London and Dubai Bureau; Writing by Matthew Tostevin and Jon Hemming; Editing by Louise Ireland, Eric Beech and Paul Simao)

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Saturday's college roundup (track, rowing, tennis): Local Hokies among NCAA track qualifiers

Daily Press

1:29 a.m. EDT, May 27, 2012

Virginia Tech teammates Ronnie Black (high jump) from Menchville High and Will Mulherin (5,000 meters) from Tabb were among the numerous athletes from many area universities who qualified for the NCAA track and field championships, thanks to their performances at the East preliminaries in Jacksonville, Fla.

Women?s rowing:

Virginia rowing team advanced all three boats from semifinals to Sunday?s grand finals on the second day of the NCAA championships on Mercer Lake in West Windsor, N.J.

Men?s tennis:

National runner-up Virginia?s two remaining singles entries lost in the NCAA quarterfinals in Athens, Ga.

No. 2 seed Mitchell Frank fell to Ohio State?s Blaz Rola 7-6 (7-5), 6-1. Alex Domijan lost 6-0, 5-7, 6-1 to top-seeded defending champion Steve Johnson, who has led Southern California to four straight team crowns ? beating U.Va. along the way each time, including in title matches the last two years.

In a doubles quarterfinal, VCU?s Alexis Heugas and Antoine Baroz lost 2-6, 6-4, 7-6 to Ole Miss brothers Chris and Marcel Thiemann.

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Briefly: What Google's Large Win Against Oracle Method for Patent ...

The "World Number of intellectual property cases" has ended, and Google emerged having a winning verdict from the extended patent showdown with Oracle.

Briefly boils lower complex occasions to provide you with the heart from the matter -- today and what it really method for tomorrow -- clearly and just.

What Is Happening: The jury in Oracle's trial against Google found the search giant didn't infringe on Google's patents because it couldn't decide whether Google's actions fell under fair use laws and regulations.

This Year, Oracle prosecuted Google for patent violation on three separate patents. Google accepted it used Oracle's Java programming language, but was adamant with equal vigor the use fell under fair use laws and regulations.

Initially, it appeared as if Oracle would emerge victorious, because the jury made the decision earlier that Google had used Java's patents -- however the jury couldn't conclude that the organization violated fair use laws and regulations, therefore it handed the win to Google.

What's Really Happening: This situation has large implications for that Android platform. Had Oracle proven Google's Android operating-system incorrectly used Java, Google might have been purchased to spend royalty obligations for many years.

Now it does not desire to make any changes, that is fantastic news for Google and Android phonemakers like Samsung, like a ruling in support of Oracle might have brought to product restrictions.

This situation was likely to set a benchmark when it comes to how much cash Google might have needed to pony up later on regarding patent violation cases. Prior to the trial, Google offered Oracle $2.8 million in damages in advance, with increased compensated each year. Oracle wanted a larger check, demanding around $1 billion in copyright damages altogether. Using the verdict in, there is no chance Google will pay out that type of money in the near future.

What's Next: Google still might have to pay Oracle some cash, with respect to the way U.S. District Judge William Alsup rules on among the last aspects of the situation. However the amount is probably pocket change in comparison as to the was up for grabs prior to the verdict.

The situation with Google and Oracle was only some of the contentious patent fight happening within the tech world, with Google's rival Apple is suing HTC and Samsung for patent violation. As the apple iphone maker isn't suing Google directly, the instances have echoes of similarity: Apple thinks Samsung and HTC have infringed on its patents, though it may be contended the phonemakers' adoption of Apple-esque technology falls under fair use.

Oracle faced Google directly rather than participating in a proxy war through certainly one of its Android phonemakers, that is how companies generally wage war with Google over Android patents. The truth that Google's legal team switched the Oracle situation around within their its client's favor demonstrates the legal muscle the internet search engine giant can flex, which may discourage potential adversaries from taking Google to the court -- including Apple.

The Takeaway: Google's victory may have major implications based on how programming language may be used, and transmits the effective message the search giant is really a formidable legal foe.

This trial also demonstrates the difficulties of intellectual property cases, especially because the jury thought Google was wrong for implementing Java with no proper patents but tend to not prove it because of the complicated wording of both patents and also the laws and regulations.

The jury's verdict could discourage tech companies from going after these type of suits later on, because it demonstrates the way a complaintant could still lose a situation even if the jury sympathized using their plight. Furthermore, the foreman noted that Google's argument it seen Java as free collaborative software swayed a few of the tech-savvy jurors, recommending jurors later on will probably pass lower similar decisions.

Briefly: What Google's Large Win Against Oracle Method for Patent Law initially made an appearance at Mobiledia on Thu May 24, 2012 12:15 pm.

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Top Advantages of On the internet Radio Stations ? Taking pleasure ...

Top Advantages of On the internet Radio Stations - Taking pleasure in Audio tracks StreamingReviewed by Ammalltravviss1984 on May 26.Rating:

On-line Stereo are the most common method for visitors to be capable of hear their favorite place even though they may not be within the array. Employing internet streaming engineering plenty of audience are now able to appreciate house music even when they are throughout another part of the world. Via on the internet r / c, audience along with followers becomes up to date along with songs and even information in the geographic area in the broadcast.
Whenever you opt to employ on the internet the air, you can anticipate much more advantages over a regular radio. As opposed to regular stereo you no longer need to concern yourself with establishing your stereo to the correct consistency.
You can forget Storage area
On the internet stereo let consumers as a way to appreciate regardless of the place can be enjoying live by making use of the World Wide Web. Right now, broadband cable connections enable several for you to straight connect with an internet music without even installing data. Picking an on-line radio stations station will in all probability play your selected sort of audio so you can free of charge the harddrive of such downloads available.
Live Anyplace Without any Disturbance
Yet another fantastic thing about on-line radios areas is that you can take pleasure in your audio live. Some individuals half way around the globe use Net connectivity to listen to music within their authentic residences. The kind of speed that we can take advantage of permits this kind of fast internet streaming. In addition, so long as you Web connection you are able to join whenever along with wherever. As it is often related on the web it?s also possible to expect significantly less disturbance.
A web based r / c place is more preferred due to its several advantages in comparison with typical radio listen closely. It is no surprise that a majority of radio stations previously shifted their particular audio online. Taking pleasure in on the web radio stations has become thousand instances less complicated compared standard being attentive.

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Anti-GM wheat crop action planned

26 May 2012 Last updated at 22:33 ET

Security around an experimental crop in a Hertfordshire field has been increased to prevent any damage during a day of action by opponents.

Campaigners against the genetically modified wheat will be kept away from the Harpenden test site, run by Rothamsted Research, on Sunday.

They are concerned about potential contamination from the cereal, but researchers say it is infinitely small.

St Albans District Council had to apply for permission for extra police powers.

It received consent of the home secretary.

The wheat project aims to see whether the modified crops can deter aphids - a major wheat pest.

Opponents are not against the trial itself, but are worried about it taking place in the open air, and the threat that the surrounding area could be contaminated.

Rothamsted Research says its work has been independently checked and that the possibility of contamination as the pollen is blown in the wind is infinitely small.

St Albans District Council is hoping for a safe, lawful and peaceful protest in a nearby park on Sunday.

'Decontamination' action

The council's executive leader, Julian Daly, said: "We are particularly concerned that a demonstration on Rothamsted's land may put historic crop trials at risk.

"Continuous trials have been under way there for over 160 years and are of international significance for the future of world farming."

Anti-GM group Take the Flour Back has vowed to "decontaminate" the site unless the research is halted.

On its website it says a walk from a nearby park will take place to the site on Sunday afternoon.

"This action is for everyone who feels able to help remove the GM crop, and for those who wish to show their support for them," it said.

Rothamsted has previously pleaded with anti-GM campaigners not to destroy their experimental plots.

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Nueva versi?n de Google+ para Android

Despu?s de que muchos nos?qued?ramos?con la duda de ?cuales?habr?an?sido las razones para que Google lanzara una nueva?versi?n?de Google+ para iOS antes que para Android?, ahora ya tenemos la?versi?n?correspondiente para Android.

En la nueva?versi?n?de Google+ para Android encontramos como principal?caracter?stica?una, totalmente, renovada interfaz de usuario, en esta nueva interfaz de Google+ para Android vemos una serie de botones en la parte superior los cuales nos van a permitir efectuar todas y cada una de las acciones que nos permite la red social.

Ademas, en esta nueva interfaz de Google+ para Android nos topamos con la agradable?opci?n?de poder iniciar ?quedadas? o ?hangouts? desde el dispositivo?m?vil, lo cual (creo) por fin animara a muchos usuarios a activar sus cuentas en la mencionada red social.

Como de costumbre, tenemos la aplicacion de Google+ para Android disponible para descargar gratis.

Enlace: Google+ para Android

Por: Juanka Mej?a 24/05/2012

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Solid Assistance Concerning How To Accept All forms of diabetes ...

May 27

Proper training is necessary when it comes to any disease. After an individual is informed about their condition they ought to try and enact modifications within their lifestyle that will advantage them, or at best restrain the signs of the ailment. Diabetes mellitus is a disease that many millions of folks accept every single day, and you will also. Teaching yourself together with the information in this post begins the golf ball rolling.

Tend not to ignore any food if you are a diabetic. Carrying out that may make you become more hungry when it is time and energy to eat and you will definitely probably consume considerably more than you would probably have or else. This can bring about greater than typical glucose levels so it ought to be avoided.check out medifast coupon codes

In case your spouse or companion is affected by diabetes, one way to assist and motivate a good life-style is working out with each other. Exercise has been shown to minimize or support turn back the effects of all forms of diabetes. Inspire your companion to go on hikes along, or find a nearby health and fitness center where you may spend time jointly as well as receiving healthful!

A fantastic breakfast food items for the Diabetic person is grapefruit! It?s been proven to aid people who have weight-loss even if they do hardly anything else. Take care that you aren?t on any pills, like atorvastatin for cholestrerol levels, who have side effects whenever you consume grapefruit. It can actually boost their strength and possibly bring about an overdose.

Like a diabetic person, ensure you consider your medicines by the due date. Confer with your medical doctor for a time table to help calculate the proper times that you can take your treatment. Physicians could instruct you to consider your pills prior to deciding to eat or when you are also getting insulin, you may be necessary to consider your pills a minimum of 30 minutes prior to.

It?s likely the details you simply read through is viewed before. It could not implement, but in cases where it will, prudence suggests that guidance should be applied. If it problems basic safety or understanding, the information in the following paragraphs will help anybody experiencing diabetic issues discern the important points from stories in relation to insulin.

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Polls on gay marriage not yet reflected in votes (The Arizona Republic)

Share With Friends: | | Politics - Top Stories News, News Feeds and News via Feedzilla.

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Distracting Decor - Lovely Listing - Odd Finds in Real Estate Listings

Two Years? You?re kidding me. I used to move a lot when I was a renter and even got to where I had a four bedroom townhouse, basement, main and 2nd, fully furnished. I could still pack in a week, move in two days, and unpack in three days, and be installed and set up by the following week. And I live with every wall area decorated with a painting, shelves and curious here and there, crap on the windowsills and every cupboard and drawer crammed. I could see it taking a month or two if you?re employed and can only work after work, but not two years unless you just ignore the job frequently.

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Metawatch ? Smartwatch for Android and iOS

  Formed by two ex leaders of?Fossil’s?Watch?Technology?Division in 2002,?Metawatch?has developed?a smartwatch in a same vein as the Pebble. The Metawatch is compatible with Android OS 2.3 and up and iPhone 4S (iOS 5+ ) and potentially any programmable device supporting?Bluetooth 2.1 and up with Serial Port Profile (SPP) connectivity, or Bluetooth 4.0 with BLE GATT [...]

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BonBon Deal of the Day: Wedding Worthy

The past few months, I?ve been writing a lot about my little sister?s wedding and incidentally, she?ll be guest posting regularly with wedding related goodies in the coming weeks! So, watch out for her fabulous posts!

As you can imagine, we?re in the throws of planning her big day, so everything from flowers to wedding day fashion are on our minds! She?ll be shopping for her wedding gown soon and once it?s chosen, we?ll be on the lookout for all the accessories that she?ll need to complete her wedding day look.

If gold is appropriate, I?m thinking these beautiful baubles would make a fabulous ear candy option! They?re definitely statement makers don?t you think?!?

So, what did your wedding day jewelry look like lovelies? I went with simple pearl and rhinestone studs, but if I had a do over, I think I would go for something a bit flashier this time!

Tagged as: BonBon Deal of the Day, Kristin, statement earrings, wedding jewelry

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Blog Archive ? Understand How Local Web Marketing Works

Local web promoting is the best tool that any small company owner can use to gain acceptance in his community. With its correct use, you can draw a great number of customers to your store with a great guarantee of raised sales. There are some categorical steps which you have to consistently observe though to make all of these a reality. They are the following.

Have A List ? Note the clients who?ve repeat transactions with you. Create a database and place the name and contact data of these purchasers in there. Thru e-mail, you can send them updates about your products and services. This a great way to reach out to your market and give them encouragement to take advantage of your offers. You can go through an Aweber tutorial to learn this process. You can bolster on your customer reach using some promotional contrivances. Perhaps, you can offer online visitors free e-book in exchange of their names and e-mails.

Sport An Interactive Website ? Effective online marketing for local businesses starts with this. More than being a well-spring of info, your site must excite to take some action. Say, you are running a small restaurant. You can produce a video that may share the recipe of your famous dishes. With it, you can set up a competition with prizes like discount coupons on set meals.

Exploit Local S.E.O Strategies ? Only a handful of home entrepreneurs understands the significance of this. It is both a skill and a science of becoming ranked first in the search engine results pages when local searches are launched. A Market Samurai tutorial can be of major help for this. If you?re able to incorporate these procedures in your promotional campaign, you can gain edge over the competition. Local web selling done this way increases the level of credibility of your brand. You are understood as leader in your industry. So, more shoppers gets drawn to your internet site.

Make A Fan Page ? Facebook has popularised the usage of fan page for distinct purposes. Thanks to this feature that small business owners can now reach as many prospect shoppers as practical. You can readily share in your fan page how your brand can enhance the day to day lives of your target audience. Other social networking sites like Twitter, Google Plus and LinkedIn are worth trying also.

Create A Blog ? A blog is intended to complement your business website. It is definitely made to bring more fun and excitement when you are sharing to your audience product launches and other promotional events. In here, you can share your private thoughts as the entrepreneur. Engaging possible clients this way stirs personal attachment to your brand. Once you can build emotional bond with your readers, it would be less complicated for you to make them purchase goods or subscribe to your services. Look into an Optimize Press tutorial to teach you the basic and advanced steps in blogging.

The developments in technology have already removed the boundaries that limit local web marketing. There are at present numerous of ways in which you can get your brand famous in your niche. All you have to do is spend some time to observe the above-mentioned tips for your business success.

Are You Looking For An Aweber Tutorial? Go Visit Our Site At http://www.daveapproved.com Today.

Tags: internet, Internet Marketing, local web marketing, marketing, online business, online marketing for local businesses, seo, site promotion, web marketing

This entry was posted on Saturday, May 26th, 2012 at 3:45 pm and is filed under Internet Marketing. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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SEO India- How to secure website from negative SEO

(Prudent Press Agency) In recent times, it has been witnessed that various organizations are availing malicious promotional tactics to defame their contemporaries. This kind of activities have not just damaged the reputation of many organizations, it has created a kind of fear in the whole industry.

This is the reason that almost every organization is giving more importance to their reputation and also carefully watching for incidences which could damage them. However, as these organizations themselves are not competent enough to do that, they are availing the services of most promising reputation service providers.

Nowadays, the practice of availing positive advertising and marketing campaigns are getting significantly reduced. Opening up of world market has also intensified the existing competition among various organizations. This is the reason, every enterprises are availing every possible method to become a leader in their respective industry.

Apart from that, there are also many advertising and marketing solution offering organizations which are regularly coming up with these malicious tricks and techniques and persuading their clients to avail them. This way every one is helping and pushing each other to carry on such negative activities. As these negative propaganda can be used against any organization. It is very important for anyone to make their reputation and most importantly themselves secure from such campaigns.

Among all, it is the online world which is the most vulnerable of such negative and malicious propaganda. To outdo their competitors, organizations are availing these negative SEO India techniques like never before. In this article we are going to discuss about some of these negative SEO India techniques:-

1. Links has always been a vital tool used by organizations to promote their online presence. However, it is these same links which many SEO India service offering organizations are using to damage the reputation and credibility of the competitors of their clients. The worst aspect of these negative link services is that it is very hard to trace their origin. So when any organization faces such kind of attacks. They should immediately inform the authorities of leading search engines. This way they can save themselves from being penalized.

2. Everything in the online world, if it is significant, instantly goes viral. So if any negative review, comment or feedback is posted against any respected and reputed organization, it can instantly attract the attention of a large volume of online users. Also, spreading of such kind of negative information can easily damage the reputation and overall sales of any organization. So it is very important that organizations should avail online reputation management services of leading SEO India service offering organization. This way they can protect themselves from any malicious targeting or activity against them.

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What is Social Networking? | Business Solutions Etc.

?Social networking, we have all likely heard of it before, but not everyone knows what it means? If you were asked to define what social networking was, would you be able to give an accurate definition. Unfortunately, most individuals cannot, even though it is likely that they participate in some form of social networking, especially online.

Social networking is defined as the grouping of individuals together into to specific groups, often like a small community or a neighborhood. Although social networking is possible in person, especially in schools or in the workplace, it is most popular online. This is because unlike most high schools, colleges, or workplaces, the internet is filled with millions, if not more, of individuals who are looking to meet other internet users and develop friendships.

When it comes to social networking online, websites are used. These websites are known as social networking websites. Social networking websites are, in a way, like an online community of internet users. Depending on the social networking website in question, many of these online community members share a common bond, whether that bond be hobbies, religion, or politics. Once you are granted access to a social networking website you can begin to socialize. This socialization may include reading the profiles or profile pages of other members or even contacting them.

The friends that you can make are just one of the many benefits to social networking online. Another one of those benefits includes diversity. Unlike in most schools or workplaces, the internet gives individuals, from all around the world, access to social networking sties. This means that although you are in the United States, you could develop an online friendship with someone in Japan. Not only will you make a new friend, you but may also learn a thing or two about a new culture.

As previously mentioned, social networking often involves grouping specific individuals or organizations together. While there are a number of social networking websites that focus on particular Internets, there are others that do not. These websites are often deemed traditional social networking websites. These types of websites typically have an open membership. This means that anyone can become a member, no matter what their hobbies, beliefs, or views are. However, once you are inside this online community, you can begin to create your own network of friends; thus eliminating others that do not meet your criteria.

If networking on the internet sounds like something you would be interested in, you are encouraged to learn more about it, such as the dangers of social networking. These dangers often involve online predators or individuals who claim to be someone that they are not. Although danger does exist with networking online, it also exists with networking out in the real world. As when you are meeting friends at a bar, school, or work, you are advised to proceed with caution online. By being aware of your surroundings and who you are talking to, you should be able safely enjoying social networking online.

Once you have learned everything that you feel you need to learn, about social networking online, you can begin to search for networking communities to join. This can easily be done by performing a standard internet search. Your search will likely return a number of results, including MySpace, Friend Wise, Friend Finder, Yahoo! 360, Facebook, Orkut, and Classmates.

Link to Business Solutions Etc. Limited. If you found this post useful, why not share it with someone?

<a href="http://bsetcetera.com/what-is-social-networking" >What is Social Networking?</a>

Related posts:

1. Using Social Networking Websites to Promote Your Blog
2. Marketing Your Business Online
3. Tracking the Results of Internet Marketing
4. Using Your Content for Internet Marketing
5. Internet Marketing and Outsourcing

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DCE Launches Multi-City Fine Art Tour : WBCitizenship: Warner ...

ORIGINAL FINE ART INSPIRED BY

THE UNIVERSE OF DC COMICS SUPER HEROES

KICKS OFF A MULTI-CITY TOUR

The ?Darkness & Light? Art Exhibit Features

An Awe-Inspiring Collection of Pop-Culture and Fine Art Interpretations

Of the World?s Most Iconic Heroes as You?ve Never Seen Them Before?

BURBANK, Calif. (May 23, 2012) ? Warner Bros. Consumer Products and?DC Entertainment yesterday premiered ?Darkness & Light: Art Inspired by Heroes & Villains, Hope & Heroism,? a collection of original artwork inspired by the universe of DC Comics and its iconic characters, including JUSTICE LEAGUE super heroes Batman, Superman and Wonder Woman, and re-imagined by exceptional contemporary artists from around the world.? To celebrate the unveiling of this one-of-a-kind collection, DC Entertainment opened the doors to its new Burbank headquarters at The Pointe with an open house and private reception.

?We work with many of these amazing artists day-in and day-out. With this project, we gave them the free reign to interpret the universe of DC Comics super heroes as they see them in their medium of choice.? What we got back was a fascinating collection of visually stunning pieces, each offering a completely unique perspective on these universally recognized characters,? said Brian Deputy, Vice President of Creative Worldwide for Warner Bros. Consumer Products and curator of the ?Darkness & Light? exhibit.

The collection, which includes more than 100 original works from artists spanning the globe and ranging in various forms, from graphic designers and painters to sculptors, will also raise awareness for DC Entertainment?s WE CAN BE HEROES giving campaign (www.WeCanBeHeroes.org).

The participating artists hail from around the globe ? as well as within the halls of Warner Bros. Consumer Products and DC Entertainment ? and bring their diverse backgrounds, unique artistic styles and perceptions of the universe of DC Comics to this collection.? Some key artists involved include Kiyoshi Nakazawa, Martin Ontiveros, Mike Palermo, Nathan Sawaya, Bwana Spoons and Amanda Visell.

The collection includes a piece by Martin Ontiveros called ?Order/Chaos,? which depicts good and evil together, rendered in ink and paint on board; Kiyoshi Nakazawa combined various media in his dramatic interpretation of Batman in ?A Great Sense of Humor;? working in steel, wood, paper, plaster and resin, Mike Palermo created ?Man of Steel? that shows that there is a hero in everyone; Amanda Visell?s piece, ?Wonder Woman,? uses paint on board to show this female super hero?s stoic but sexy power; and an oversized original work of art by legendary comics artist and DC Entertainment Co-Publisher Jim Lee, which utilizes spray paint and acrylic on canvas to highlight the profile of Batman with a color scheme inspired by the colors of Africa ? yellow, green, red and black.

Original art by Nathan Mochizuki.

?This distinctive collection unites the comic industry with contemporary artists, highlighting each artist?s individuality and style,? continued Deputy.??The creators each had a deep connection to the characters and worlds of DC Comics and this passion is brought to life and captured for all to see through this incredibly vivid collection.?

Up next, ?Darkness & Light? will take to the road with a series of public exhibitions that will continue to benefit and raise awareness for?WE CAN BE HEROES, including a showing in San Diego at the premier Michael J. Wolf gallery during Comic-Con International from July 13-15. Additional exhibition dates and locations to be announced this summer.

WE CAN BE HEROES utilizes the iconic JUSTICE LEAGUE to help raise awareness and funds for three nonprofit partners ? Save the Children, International Rescue Committee and Mercy Corps ? who are delivering aid to millions of people in need of critical assistance in the famine-ravaged Horn of Africa.? For more information on DC Entertainment?s WE CAN BE HEROES campaign, please visit www.WeCanBeHeroes.org.

To learn more about DC Entertainment and its iconic characters, please visit www.dccomics.com.

DC Entertainment Executives: EVP of Sales & Marketing John Rood, President Diane Nelson, Chief Creative Officer Geoff Johns and Co-Publisher Jim Lee attend the Warner Bros. Consumer Products and DC Entertainment 'Darkness & Light' art exhibit premiere and open house at DC Entertainment's new offices.

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Interactive PC Certification Courses In Cisco CCNA, Computers And ...

If you want training in Cisco, it?s most likely that the CCNA is what you?ll need. Cisco training is designed for people who want to learn about network switches and routers. Routers connect computer networks to other networks of computers via the internet or dedicated lines.

Because routers join up networks, find a course that features the basics on networks (for example Network+, perhaps with A+) before getting going with CCNA. It?s essential to have this background understanding on networks before you commence any Cisco training or you may be out of your depth. When you?ve qualified and are on the job market, employers will be looking for networking skills alongside your CCNA.

It?s a good idea to find a tailored course that will systematically go through everything in advance of starting your Cisco CCNA course skills.

It?s usual for students to get confused with one area of their training which is often not even considered: The breakdown of the course materials before being couriered to your address. Training companies will normally offer a 2 or 3 year study programme, and courier the materials in pieces as you complete each section or exam. On the surface this seems reasonable ? until you consider the following: How would they react if you didn?t complete each section within the time limits imposed? And maybe you?ll find their order of completion won?t fit you as well as some other structure would for you.

The ideal solution is to have all the learning modules couriered to you right at the start; the complete package! Then, nothing can hinder your capability of finishing.

Many commercial training providers only provide office hours or extended office hours support; It?s rare to find someone who offers late evening or full weekend cover. Many only provide email support (too slow), and telephone support is usually to a call-centre that will take the information and email an instructor ? who will attempt to call you within 24-48 hrs, when it suits them. This is not a lot of use if you?re lost and confused and can only study at specific times.

The very best training providers have many support offices active in different time-zones. By utilising an interactive interface to seamlessly link them all, any time of the day or night, there is always help at hand, without any contact issues or hassle. If you accept anything less than direct-access 24?7 support, you?ll quickly find yourself regretting it. You might not want to use the service throughout the night, but you?re bound to use weekends, early mornings or even late evenings at some point. Check out You could try these out for quality details.

Commercial certification is now, undoubtedly, taking over from the traditional academic paths into the industry ? but why has this come about? With the costs of academic degree?s spiralling out of control, alongside the IT sector?s growing opinion that key company training is often far more commercially relevant, we have seen a big surge in Microsoft, CompTIA, CISCO and Adobe based training courses that supply key solutions to a student for considerably less. Patently, a necessary degree of closely linked knowledge has to be taught, but focused specifics in the required areas gives a vendor trained student a distinct advantage.

In simple terms: Commercial IT certifications give employers exactly what they?re looking for ? it says what you do in the title: i.e. I am a ?Microsoft Certified Professional? in ?Windows XP Administration and Configuration?. Therefore an employer can identify exactly what they need and what certifications are needed for the job.

We can all agree: There really is no such thing as individual job security anywhere now; there?s really only industry or business security ? as any company can drop any single member of staff if it meets the company?s business needs. It?s possible though to reveal security at the market sector level, by digging for areas that have high demand, together with work-skill shortages.

The IT skills shortage throughout the United Kingdom falls in at approx twenty six percent, as reported by the most recent e-Skills study. Meaning that for each 4 job positions that are available around IT, we?ve only got three properly trained pro?s to fulfil that role. Well trained and commercially grounded new professionals are correspondingly at a total premium, and it seems it will continue to be so for a long time to come. We can?t imagine if a better time or market state of affairs will exist for acquiring training in this swiftly emerging and evolving market.

Pop to this website for up to date data? www.computer-networking-course.co.uk and an update on CompTIA Networking Courses.

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Flexing Your Minority Shareholder Muscle | Baton Rouge Business ...

The question is often asked by minority shareholders, "Do I have any rights relative to the majority shareholders?" The simple answer is "Yes", but the extent of these rights may vary.

The question is often asked by minority shareholders, "Do I have any rights relative to the majority shareholders?" The simple answer is "Yes", but the extent of these rights may vary.

Normally a minority shareholder is a shareholder who has less than 50% of the outstanding shares of a company with the majority shareholder(s) having over 50% of the outstanding shares. The size of the company (closely held company v. publically traded company) usually determines the voting power of the shareholders and how the minority interest is actually affected. Publically traded corporations normally have numerous shareholders who may combine their voting interest to control how the company is run, whereas closely held corporations usually have very few shareholders. Often times, closely held corporations have one or two majority shareholders who in turn control how the company is run, thereby suppressing the rights of the minority shareholder(s).

Unless otherwise stated in the articles of incorporation or bylaws of the company, the majority rule is used regarding any decision brought before shareholders, except the appointment of the board of directors. La. R.S. art. 12:75(I). Therefore, unless the articles or bylaws allow for cumulative voting or some other form of minority voting protection, a minority shareholder will be at the mercy of the majority shareholder when it comes to making decisions for the company or electing directors and officers to make decisions for the company. As one may suspect, this control can cause a serious rift between the shareholders which often leads to a falling out.

However, Louisiana law offers some remedy for minority shareholders who feel they are being treated unfairly. One of the more gutsy options for a minority shareholder is to file a petition for involuntary dissolution of the company. La. R.S. art. 12:143. A minority shareholder may have grounds for involuntary dissolution if can prove that the directors or officers of the corporation have been guilty of gross and persistent ultra vires acts and thereby breached their fiduciary duty to the company. However, this type of action carries a very serious burden of proof and courts normally do not find directors guilty of ultra vires actions. One specific case did rule in favor of a minority shareholder and force liquidation of the company whereby the minority shareholder proved that the majority shareholders, who were also serving as the directors of the company, had conducted ultra vires activities. Gooding v. Millet, 430 So.2d 742 (La. App. 5^th Cir. 1978). The court in Gooding determined that the corporate officers were guilty of gross and persistent ultra vires actions when the officers failed to issue stock certificates, failed to hold annual meetings, failed to keep adequate financial records and granted themselves salaries without a proper vote at a shareholders meeting.

Another option for a minority shareholder to flex their muscle is through a writ of mandamus. A writ of mandamus directs a corporate officer to perform their required duties. La. C.C.P. art. 3861. These required duties include the recognition of rights of the shareholders or some other obligation required according to the bylaws of the corporation. La. C.C.P. art. 3864. One of the more common mandamus actions is the shareholders' ability to inspect financial records of the corporation, a right that courts often recognize in Louisiana. Feil v. Greater Lakeside Corporation, 31 So.2d 520 (La. App. 5^th Cir. 1/26/10). A mandamus action lets the controlling shareholder(s) know that the minority shareholder is aware of their rights and is not afraid of using the legal system to enforce those rights.

The above mentioned remedies are just a couple of examples of the rights provided to minority shareholders under Louisiana law. While being a minority shareholder can be frustrating at times, it is important to remember that you do have options. If you have any questions concerning your rights as a corporate shareholder, please contact our office.

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